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NOL Tehnology


Monitoring the intraoperative nociception level may enable clinicians to personalize and optimize the analgesic administration, thus avoiding excessive use or under use of opioids, that may result in significant complications.

Each Year, Worldwide:

UP TO 50%

Of surgical patients suffer from moderate to severe post-operative pain.


Of surgical patients suffer from adverse events due to analgesic medications, leading to:

  • 3.3 extra days of hospitalization
  • 27% extra cost per patient
  • Increase in re-admissions

Missing a Piece?


While Hypnosis and Immobility are continuously and specifically monitored, analgesia is assessed indirectly through changes in hemodynamic and clinical parameters (Heart Rate, Blood Pressure, Sweating, Tearing, etc.).

These parameters are not specific to nociception, and may change in response to other causes as well.

Consequently, patients may be given insufficient analgesia, which may promote postoperative pain, or excessive analgesia, which may cause respiratory complications, nausea and vomiting, hyperalgesia, and other complications.


Leveraging patented NOL™ technology, the PMD-200™ is a non-invasive and continuous pain monitoring device.

By using the PMD-200™ in operating rooms, where patients under general anaesthesia are unable to communicate their pain, clinicians are able to assess nociception, and better titrate analgesic medications – avoiding excessive use or underuse, that may result in significant complications.

Multi-Parametric Approach

Recognizing the complex nature of pain, the NOL™ technology considers multiple nociception-related physiological parameters and its various derivatives.

Advanced Algorithms

Advanced algorithms process the multiple data streams, identify the pain-related patterns, and reflect a patient’s nociceptive state.

NOL™ (Nociception Level) Index

  • An objective indicator for the presence and severity of nociception.
  • The only multi-parameter nociception index, based on the physiological integrated response to noxious stimuli.
  • Calibrated to an individual’s baseline.
  • Clinically validated as superior to other nociception indicators.

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